Development, characterization and anti-Mycobacterium tuberculosisactivity of solid lipid nanoparticles for oral Piper corcovadensisroots extract delivery
نویسندگان
چکیده
The present study thus aimed at the development and physicochemical characterization of solid lipid nanoparticles loaded with crude extract Piper corcovadensisroots (SLN-CEPc) chitosan-coated withcrude P. (C-SLN-CEPc), as well determination its antimycobacterial activity against Mycobacterium tuberculosisH37Rv, cytotoxicity Vero cell line evaluation in hemolysis assay. Both formulations containing encapsulated showed high encapsulation efficiency, formed by a monodispersed system small spherical particles, there was no aggregation particles. In biological assays, SLN-CEPc C-SLN-CEPc promising anti-M. tuberculosisactivity minimum inhibitory concentration (MIC) 12.5 μg/mL, whereas cytotoxic concentrations obtained 50% (CC50) cells were 60.0 70.0 respectively. Therefore, nanoencapsulation satisfactory results, justifying usage new products.
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ژورنال
عنوان ژورنال: Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants
سال: 2023
ISSN: ['0717-7917']
DOI: https://doi.org/10.37360/blacpma.23.22.6.55